Obesity, weight loss change splicing pattern of obesity, type 2 diabetes genes

Alternative splicing of obesity and type 2 diabetes related genes may contribute to the pathophysiology of obesity, according to research. Obesity leads to changes in the splicing pattern of metabolically relevant genes such as TCF7L2 and INSR, resulting in impaired insulin action. However, weight loss, induced by either obesity surgery or a very low-calorie diet, reverses these changes. The findings increase our understanding of splicing dysregulations in obesity and can result in a new, more targeted treatment and more accurate diagnostics of metabolic disorders.

from Fitness News — ScienceDaily http://bit.ly/1Kmgz1O
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